Charles University, Faculty of Medicine in Pilsen
Charles University (Universitas Carolina) was founded by Roman Emperor and King of Bohemia Charles the Fourth in 1348. Faculty of Medicine in Pilsen (CU-FMP) is one of the 17 faculties of Charles University settled in the west-bohemian city of Pilsen. Except of education in General Medicine and Dentistry, CU-FMP is active in biomedical research in the fields of the replacement of function of vital organs like liver, kidney and homeostasis, including clinical experimental work on large animal models and modeling of the sepsis nad organism response on systemic infections. The experimental research takes place in Biomedical Center. The Department of the Imaging, the united department of Medical Faculty and University Hospital in Pilsen is active in the experimental research in Biomedical Center of the advanced imaging techniques including the imaging of animal experiments using computed tomography.
The Imaging research program contains the development of new imaging techniques using computed tomography, the latest program started since 2020 is involved in the development of the photon-counting CT. The world-wide first human scans of the ill patients with photon-counting CT using clinical-prototype were performed in Pilsen during 2020 in collaboration with Siemens-Healthineers CT development and research group. The collaboration resulted in the first publication of clinical results with photon-counting CTin humans. Contemporary, the current research continues in the development of new imaging ways using dual-source photon-countin CT. The photon-counting CT program followed the previous research on the field of the cardiovascular imaging and dual-energy imaging of tissues including brain, lungs and kidneys, and the perfusion imaging of the myocardium.
Except the imaging using computed tomography, the second flagship of the research is the molecular imaging using hybrid imaging with PET/CT and PET/MRI with advanced radoopharmaceuticals or imaging concepts, the most important are imaging of the inflammation in immunocompromised patients, the advanced imaging of malignant tissues targeting proliferation, microenvironment and tissue hypoxia. The Department of the Imaging of Medical Faculty and University Hospital in Pilsen is equipped by 6 computed tomography suites, 3 suites of magnetic resonances, 3 suites of hybrid imaging (PET/CT, PET/MRI, SPECT/CT), and two cath-labs, the staff of 190 people includes 60 medical doctors.
Role in the project
Charles University, Faculty of Medicine in Pilsen, Department of the Imaging, provides imaging and clinical data and contributes imaging experience in cardiovascular imaging with advanced applications of photon-counting CT to the AI-POD project.
The key publications are Ferda J, Vendiš T, Flohr T et al. Computed tomography with a full FOV photon-counting detector in a clinical setting, the first experience. Eur J Radiol. 2021; Ferda J, Ferdová E, Hes O, et. al. PET/MRI: Multiparametric imaging of brain tumors. Eur J Radiol. 2017; Ferda J, Hromádka M, Baxa J. Imaging of the myocardium using (18)F-FDG-PET/MRI. Eur J Radiol. 2016; Ferda J, Ferdová E, Záhlava J, Matejovic M, Kreuzberg B. Fever of unknown origin: a value of (18)F-FDG-PET/CT with integrated full diagnostic isotropic CT imaging. Eur J Radiol. 2010; Ferda J, Novák M, Mírka H et al.. The assessment of intracranial bleeding with virtual unenhanced imaging by means of dual-energy CT angiography. Eur Radiol. 2009